If you will look at the recent number of deaths due to the COVID-19 pandemic, you will realize that it is having a bigger toll on men as opposed to women. This observation has stirred a lot of heated debate in the medical and scientific communities regarding what could be the possible underlying reason/s behind it.
One conjecture, plausible enough to be looked into by the experts has something to do with the male sex hormone, testosterone. Medical professionals, whose specialty is in this area, believe that the male sex hormone comes with an inherent dampening impact on the male immune system.
Those who support this supposition are convinced that testosterone makes men more susceptible to the novel coronavirus.
“How can this be?”
This is the million-dollar question being asked by the vast majority of trt Brisbane doctors. According to scientific evidence, estrogen plays a key role in improving the female immune system and may also enhance immune inflammation. On the other hand, the male sex hormone, testosterone comes with a contrasting impact because it dampens immune response.
This explains the reason why women have less than severe infections when they contract a serious illness but the opposite of which is true to men. Besides, it significantly contributes to the stronger immune responses of women’s bodies to vaccinations (basically, these are less potent versions of the virus).
If a man happens to have a higher testosterone level, the odds are high that he may be suffering from weakened immunity. This usually manifests in having low antibody responses, particularly to annual vaccinations for flu.
This brings us to an assumption, general perception of many of us, that men have a natural susceptibility to suffering more intensely from bacterial infections, but more so when it comes to contracting a deadly virus much like the one that leads to COVID-19.
Are There Any Trade-Offs To This?
A significant portion of the research done concerning the supposed suppressing impact of the male sex hormone, testosterone, on a man’s immune system centered mostly on individual immune cell types or immune function. However, we need to keep in mind that the human immune system is as intricate as intricate can be. It is made up of many different types of cells, tissues, and organs, and together they create a complex response to a threat of possible infections. We can classify this response into 2 categories, adaptive immunity, and innate immunity.
The best way to describe innate immunity is that it takes place within hours, so it is rapid and also nonspecific which means to say that it is one of the human body’s frontline defenses. It is programmed to target all kinds of foreign invaders. In addition to that, it retards infections up until the time comes that adaptive immunity is fully developed.
As for the acquired or adaptive immunity, this is a bit more complex in such a way that it will require a much longer time to process and identify a foreign matter invading the body before it can start producing specific antibodies that will take charge of it.
Long after the threat has been eradicated, the body’s adaptive system of immunity “remembers” it fully. This causes the body to make a similar response to the same pathogen but way faster, power, and more efficiently.
According to TRT Brisbane doctors, adaptive immunity is energetically taxing on the human body. What does this mean to say? This signifies that men who happen to have high T-levels in their system, the energy-hog actions such as risk-taking behavior, sexual appetite, and increasing muscle strength, all these would not necessarily prioritize adaptive immunity.
So much so that when men become seriously ill or acquire an infection in their bodies, the natural tendency of their testosterone level is to take a plummeting action. One way to explain this is that by moving energy away from every single high-energy consuming task, that amount of energy can be diverted to strengthening immune response instead.
Overall, testosterone can suppress the immune system or it can have a strengthening effect on it. But there are also occasions that it will not be impacted in any way.
With regard to these varying results in different investigations, it only goes to show that if you will only gauge certain immune features with respect to testosterone itself may not provide us with any solid immune capabilities of the body of a man.